tinnituspatient.de - The Informative Website For Chronic Inner-Ear-Patients

International Studies demonstrates the evidance of Low Level Laser Therapy.

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Studies overview:

Fields of applications and researches.

Dr. Wildens researches.

TINNITUS – POSITIVE STUDIES ON PUBMED

Other positive studies not in PUBMED

TINNITUS – negative Studies on the PUBMED, it is important to look closer to that studies.


The international LLLT-research shows a wide field of applications and researches.

It's not only the ear cells softlaser is good for.

The speciality of the LLLT-studies over all different applications is, that they show an homogeneous effect to the human and also animal cells:
Laserlight in the right quality improves the biological processes within the cells, so that the different recovery processes will be improved too.

To define the right quality is very complex and it is the key of success of a LLLT. It makes clear, that there are so different studies existing to the LLLT.
Here you can get this important informations:

2009 Harvard University of Massachusetts - Biphasic Dose Response in Low-Level-Light-Therapy.

Thor Laser 2008: LLLT – DOSE RATE EFFECTS

LASER research overviews.


Thor-Laser: LLLT Research Abstracts.
RJ-Laser: various links leading to summaries of international researches, abstract and studies about laser therapy.

The LaserWorld of the Swedish Laser Medical Society.
LaserWorld
LaserWorld - FAQ - frequently asked questions about laser therapy
LaserWorld - Change will come! Jan Tunér

Samples of different studies

Here is a good sample of a study in case of macular degeneration.
Study Lasertherapy at AMD

Another study shows the efficacy of low-level laser in case of neck pain. A systematic review and meta-analysis of randomised placebo or active-treatment controlled trials.
The Lancet 12/2009: Efficacy of low-level laser therapy in the management of neck pain

Provided that basic principles of surgical practice have been achieved, the use of long-acting local anesthetics and low-power laser irradiation enables the best postoperative analgesic effect and the most comfortable postoperative course after surgical extraction of LTMs.
PubMed August 2010 Postoperative analgesia after lower third molar surgery: contribution of the use of long-acting local anesthetics, low-power laser, and diclofenac.

Does Low-Level Laser Therapy Have an Antianesthetic Effect? A Review
Photomedicine and Laser Surgery Volume 28, Number 6, 2010 - Does Low-Level Laser Therapy Have an Antianesthetic Effect? A Review

Many doctors are using Softlaser for different applications. There are many new applicatons every year.
Dr. Wilden uses softlaser in a wide field of applications. In the focus of this website is softlaser in the case of inner ear diseases.


Dr. Wildens researches and studies.

Wilden, Dindinger 1996: Treatment of chronic diseases of the inner ear with low level laser Therapy (LLLT): Pilot project.

Wilden, Karthein, 1998: Import of radiation phenomena of electrons and therapeutic low-level laser in regard to the mitochondrial energy transfer.

Here are more scientologic works of Dr. Wilden: "Publications of Dr. Wilden "
At many international congresses he referates with positive resonance about his researches.

15th International Congress of EMLA (European Medical Laser Association) in Helsinki (August 20-23, 2010)


Studies of the last years demonstrate the working of the softlaser at inner ear problems
PUBMED - the U.S. National Library of Medicine gives a good overview about that.

Tinnitus – positive Studies on PUBMED

At first a very new study by Dr. Rhee which confirms the effects of LLLT in a test with rats.
Effect of low-level laser therapy on cochlear hair cell recovery after gentamicin-induced ototoxicity.

Gold standard - RCT
Effectiveness of combined counseling and low-level laser stimulation in the treatment of disturbing chronic tinnitus.
Cuda D, De Caria A.
Int Tinnitus J. 2008
Multimodal therapy for chronic tinnitus.
Hahn A, Radkova L, Achiemere G, Klement V, Alpini D, Strouhal J.
Int Tinnitus J. 2008

Gold standard - RCT
Effectiveness of transmeatal low power laser irradiation for chronic tinnitus
Gungor A, Dogru S, Cincik H, Erkul E, Poyrazoglu E.
J Laryngol Otol. 2008 May

Gold standard – RCT / This is a laser light penetration study
Neural correlates of transmeatal cochlear laser (TCL) stimulation in healthy human subjects.
Siedentopf CM, Ischebeck A, Haala IA, Mottaghy FM, Schikora D, Verius M, Koppelstaetter F, Buchberger W, Schlager A, Felber SR, Golaszewski SM.
Neurosci Lett. 2007 Jan 16
This study of the Uni Innsbruck we have here complete to read. Transmeatal cochlear laser treatment corresponds well to brain areas of patients with tinnitus.
Siedentopf study: Transmeatal cochlear laser treatment corresponds well to brain areas of patients with tinnitus.
Neurosci Lett. 2007 Jan 16
Transmeatal cochlear laser (TCL) treatment of cochlear dysfunction: a feasibility study for chronic tinnitus.
Tauber S, Schorn K, Beyer W, Baumgartner R.
Lasers Med Sci. 2003
Combined laser-EGb 761 tinnitus therapy.
Hahn A, Sejna I, Stolbova K, Cocek A.
Acta Otolaryngol Suppl. 2001
Efficacy of transmeatal low power laser irradiation on tinnitus: a preliminary report.
Shiomi Y, Takahashi H, Honjo I, Kojima H, Naito Y, Fujiki N.
Auris Nasus Larynx. 1997
Results of combined low-power laser therapy and extracts of Ginkgo biloba in cases of sensorineural hearing loss and tinnitus.
Plath P, Olivier J.
Adv Otorhinolaryngol. 1995

HYPERACUSIS – POSITIVE STUDIES ON PUBMED

Pain Threshold Improvement for Chronic Hyperacusis Patients in a Prospective Clinical Study.
Zazzio M.
Photomed Laser Surg. 2009 Oct 12.
Transmeatal low-level laser therapy for chronic tinnitus with cochlear dysfunction.
Teggi R, Bellini C, Piccioni LO, Palonta F, Bussi M.
Audiol Neurootol. 2009


More positive Studies (Not from PUBMED)

A study of the usefulness of LLLT, Tauber S, Schorn K, Beyer W,Baumgartner R. department Ohrheilkunde, Ludwig - Maximilians - University Munic, Germany, (from 2003).
Usefulness study Uni München
The authors find it useful and recommend some double blind studies to show the evidence.

A double blind study of M. Prochazka, M.D., Private Rehab Clinic "Jarov", Prague, CZ and Ass. prof. A. Hahn, ENT Clinic, FNKV Faculty Hospital, Prague, CZ with 200 Patients over 3 years with positive results.
Study Prochazka

A study of the TinniTool Earlaser from DisMark. Dr. Domenico Cuda and Dr. Antonio de Caria, University Piacenza (Italy), demonstrates the working and the good nature of the LLLT, too.
Study TinniTool EarLaser

Study showing the effectiveness of soft laser therapy for tinnitus and sensory hearing loss.
Dr. Mohammad Al-Masri, Ph.D.; Lina Abu Khader, MSc., Mohammad Tawalbeh,AL-Ahliyya Amman University, Audiologic-department
Study Dr. Al-Masri

Effectiveness of transmeatal low power laser irradiation for chronic tinnitus
A GUNGOR, S DOGRU, H CINCIK, E ERKUL, E POYRAZOGLU
Gungor study 2007. Prospective, randomised, double-blind study.

Study lasertherapy in case of Morbus Menière (Jan. 2006 - Feb. 2007).
Teggi R., MD, Bellini C., MD, Fabiano B., MD, Bussi M., MD, HNO-Abteilung IRRCS San Raffaele Spital, Vita-Salute University Milano, Italy.
Study Morbus Menière

A Trial of Low Level Laser Therapy for Reduction of Tinnitus Symptoms (2004).
Quittner M.G., BAppSc (Physio), Healesville Physiotherapy, Victoria, Australia.
A Trial of Low Level Laser Therapy for Reduction of Tinnitus Symptoms


TINNITUS – negative Studies on the PUBMED - it is important to look closer to that studies.

LOW DOSES – FEW TREATMENT SESSION – LONG TREATMENT INTERVAL
Jack A. Vernon is part of this study – he is one of the main characters who are pro TRT.
Transmeatal low-power laser irradiation for tinnitus.
Nakashima T, Ueda H, Misawa H, Suzuki T, Tominaga M, Ito A, Numata S, Kasai S, Asahi K, Vernon JA, Meikle MB.
Otol Neurotol. 2002 May

THE TWO ARTICLES ARE THE SAME STUDY
Frank Mirz is pro TRT and he is working with counseling.

Treatment of tinnitus with low-intensity laser
Mirz F, Zachariae B, Andersen SE, Nielsen AG, Johansen LV, Bjerring P, Pedersen CB.
Ugeskr Laeger. 2000 Jun 19

The low-power laser in the treatment of tinnitus.
Mirz F, Zachariae R, Andersen SE, Nielsen AG, Johansen LV, Bjerring P, Pedersen CB.
Clin Otolaryngol Allied Sci. 1999 Aug

NOT THOROUGHLY SPECIFIED
In a mail communication with Rogowski he could not properly specify the lasers used.

Low-power laser in the treatment of tinnitus--a placebo-controlled study
Rogowski M, Mnich, S, Gindzienska, E, Lazarczyk, B
Otolaryngol Pol. 1999

NOT THOROUGHLY SPECIFIED
Low doses that seem to be only irradiated via the mastoid bone.

Soft-laser/Ginkgo therapy in chronic tinnitus. A placebo-controlled study.
von Wedel H, Calero L, Walger M, Hoenen S, Rutwalt D.
Adv Otorhinolaryngol. 1995

NOT THOROUGHLY SPECIFIED
Low doses administrated.

Soft laser therapy in combination with tebonin i.v. in tinnitus
Partheniadis-Stumpf M, Maurer J, Mann W.
Laryngorhinootologie. 1993 Jan


There have been done some studies demonstrating the usefulnes of LLLT. In general it is to say, studies with too less energy brings less results or nothing.
Studies with enough energy had good results even if they use some other parameters (wave length and so on).

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